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The Meat Papers Contradicted Their Own Data

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The meat industry’s own study concluded that meat consumption increased the risk of cancer, heart disease, diabetes, and premature death. A series of papers published in the Annals of Internal Medicine that “largely discounted all but the highest quality randomised studies…reached a conclusion directly contrary to the public health advice we’ve heard for years.” They suggested that we should continue our current consumption of red and processed meats. The authors based their exclusion of evidence on the so-called GRADE (Grading of Recommendations Assessment, Development, and Evaluation) criteria, which were mainly created for evaluating evidence from drug trials. We need randomized, double-blind, placebo-controlled trials for drugs, but the “strictness of these criteria will probably cause evidence for just about every dietary, lifestyle, and environmental factor related to chronic disease to be graded as ‘low’ or ‘very low.’ If the GRADE criteria were used to evaluate the evidenc...
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The Many Conflicts of Interest Behind the Meat Studies

The same person paid by Big Sugar to downplay the risks of sugar was paid by Big Meat to downplay the risks of meat. A series of articles published in the Annals of Internal Medicine recommending people just keep eating their meat was decried by nutrition researchers as “irresponsible and unethical,” a “travesty of science,” an “assault on public health,” and the “most egregious abuse of evidence” that they had ever seen. There were calls for retraction even before it was published from eminent public health leaders, including a former U.S. Surgeon General, a former president of the American College of Cardiology, and the directors of preventive medicine and nutrition institutes from Harvard, Yale, Tufts, and Stanford. In my last blog, I explained the how , the method by which they manipulated the science, but never really got to the why . As I discuss in my video Conflicts of Interest in the Annals of Internal Medicine Meat Studies , the lead author’s similar attempt to discredit...
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Meat Studies Fail to Apply GRADE Properly

The meat industry comes up with a perversion of evidence-based medicine. A series of articles published in the Annals of Internal Medicine culminated in a recommendation suggesting people keep eating red and processed meat. Nutrition researchers blasted these articles. The chair of the nutrition department at Harvard called it “a very irresponsible public health recommendation,” and the past Harvard nutrition chair was even less restrained. “It’s the most egregious abuse of data I’ve ever seen,” said Walter Willett. “There are just layers and layers of problems.” Let us start to pick through these layers. The first of “several serious weaknesses” was that the analyses and recommendations were largely based on the so-called GRADE criteria (Grading of Recommendations, Assessment, Development, and Evaluation), which I talked about in my last blog. The authors erred by applying the GRADE tool, since that was designed for drug trials. As I discuss in my video Failing GRADE for Ann...
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When Should We Rely on Observational Studies?

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How legitimate is the common corporate criticism of the scientific nutrition literature that the credibility of observational studies is questionable? While randomized controlled trials are highly reliable in assessing interventions like drugs, they’re harder to do with diet. Dietary diseases can take decades to develop. People can’t eat placebo food, and it’s difficult to get them to stick to assigned diets, especially for the years it would take to observe effects on hard endpoints like cancer or heart disease. That’s why we have to use observational studies of large numbers of people and their diets over time to see which foods appear to be linked to which diseases. And interestingly, if you compare data obtained from observational population studies versus randomized trials, on average, there is little evidence for significant differences between the findings. The effects were not only in the same direction, but also of the same general magnitude in about 90% of the treatments...
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Big Sugar Twists the Science behind the Dietary Guidelines

How did Big Corn Syrup and other corporate sugar titans hijack the scientific process? In 2016, a Washington-based lobby group published a scientific review that concluded the evidence behind guidelines recommending limits on added dietary sugar was “low quality” and didn’t “meet criteria for trustworthy recommendations.” This was a group funded by multinational food and agrochemical companies, from Coca-Cola to Monsanto to the captains of corn syrup, accused of “hijacking the scientific process in a disingenuous way to sow doubt and jeopardize public health.” But exactly how did they get away with it? As I discuss in my video How Big Sugar Manipulated the Science for Dietary Guidelines , the lobby group questioned “the scientific basis of guideline recommendations on sugar intake” in its paper titled just that. Using the GRADE approach, they concluded that “the overall quality of evidence to support [such] recommendations was low to very low.” GRADE stands for the Grading of Reco...
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The Corporate Playbook Behind Undermining Dietary Guidelines

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International Life Sciences Institute, a nonprofit, is accused of being a front group for Coca-Cola and other junk food giants. In 2019, a series of reviews was published in the Annals of Internal Medicine that concluded the same thing that past reviews have concluded : Adhering to dietary patterns that are lower in red or processed meat intake may result in decreased risks for premature death, cardiometabolic disease and mortality (meaning the risk of getting and dying of diseases like heart disease and type 2 diabetes), and getting cancer and dying from it. Therefore, they concluded in their Dietary Guideline Recommendations, “continue current unprocessed red meat consumption” and “continue current processed meat consumption.” Wait, what? Despite the increased risks of premature death, cancer, heart disease, and diabetes, the advice was essentially keep eating burgers and bacon ? To understand what happened, we have to go back to 2015. The Dietary Guidelines for Americans ha...
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The Burden of Weight Bias

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Please note: This blog and its accompanying video discuss the important and troubling issue of weight bias and discrimination, which may be a sensitive topic for some readers. How might weight stigma be a vicious cycle? Although total fasting can dramatically increase blood levels of the stress hormone cortisol , as much as doubling within five days, dieting alone does not. There is , however, a way stress and obesity could turn into a vicious cycle: weight stigma. Across thousands of individuals followed for four years, those reporting discriminatory experiences had more than twice the odds of becoming obese. Those who started out obese had more than three times the odds of staying that way compared to those who started at the same weight but did not experience discrimination. Now, this could be from stress-induced eating on one side of the calorie-balance equation or stigma- induced exercise avoidance on the other. Obese individuals with more frequent experiences with weight ...
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